e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron letters
The practical procedure for a preparation of 1-chloroalkyl p-tolyl sulfoxides in high optically active form: A very short synthesis of optically active disparlure
Abstract A chlorination of optically active alkyl p-tolyl sulfoxides with N-chlorosuccinimide in dichloromethane in the presence of potassium carbonate afforded optically active 1- chloroalkyl p-tolyl sulfoxides in 87–94% ee (88–94% chemical yields). The optically active chloroalkyl sulfoxide was applied to a synthesis of optically active (+)-disparlure.
