Abstract A number of N-arylisoxazol-5 (2H)-ones (aryl= phenyl, isoquinolin-1-yl, quinolin-2- yl, 2-phenylquinazolin-4-yl and benzothiazol-2-yl) have been reacted with lithium azide to give 2-(1-aryltetrazol-5-yl) acetic esters, which have been C-methylated and hydrolysed. The resulting 2-(1-aryltetrazol-5-yl) propanoic acids had low antiinflammatory activity, as judged by inhibition of synthesis of prostaglandin PGE 2 or tumour necrosis factor α.
