Tetrahedron

Synthesis and conformational properties of model dipeptides containing novel axially chiral α, β-didehydroamino acids at the (i+ 1) position of a β-turn conformation

C Cativiela, MD Díaz-de-Villegas, JA Gálvez, G Su

Index: Cativiela, Carlos; Diaz-De-Villegas, Maria D.; Galvez, Jose A.; Su, Guifa Tetrahedron, 2004 , vol. 60, # 51 p. 11923 - 11932

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Citation Number: 8

Abstract

A series of model dipeptides containing some novel axially chiral α, β-didehydroamino acids at the (i+ 1) position has been synthesised by reaction of the corresponding 4-(4- alkylcyclohexylidene)-2-phenyl-1, 3-oxazol-5 (4H)-one with (S)-phenylalanine cyclohexylamide. The conformations of two dipeptides in the crystal state have been studied by X-ray diffraction crystallographic analysis. The backbone torsion angles suggest that ...