Synthesis of Bis (deoxyribonucleoside) Phosphoromorpholidate Derivatives for Oligodeoxyribonucleotide Preparation by Use of a Selective Phosphitylating Reagent

…, S Yamoto, S Maikuma, K Honda, T Shimidzu

Index: Ozaki; Yamoto; Maikuma; Honda; Shimidzu Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 12 p. 3869 - 3876

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Citation Number: 7

Abstract

Sequence-defined bis (deoxyribonucleoside) phosphoromorpholidate derivatives as stable intermediates to prepare oligodeoxyribonucleotides have been synthesized using morpholinodi (1-tetrazolyl) phosphine as a phosphitylating reagent. The general procedure is composed of following steps (in situ); a) a reaction of 5′-O-protected deoxyribonucleoside with morpholinodi (1-tetrazolyl) phosphine (phosphitylation), b) a ...