A novel series of N-[(2-benzothiazolylthio) alkyl]-N'-hydroxyurea derivatives (9-25) was synthesized and evaluated for biological activity as inhibitors of 5-lipoxygenase both in vivo (mouse zymosan peritonitis assay) and in vitro (Ca2+ ionophore-stimulated human peripheral blood leukocyte model). The compounds of this series were based on the corresponding hydroxamic acid derivatives (1, 3, 4, and 5) which were moderately active ...
![Benzothiazole, 2-[(isocyanatomethyl)thio]- (9CI) Structure](https://image.chemsrc.com/caspic/224/92137-10-5.png)
