Summary Starting with isobutyric acid (2) and using a microbiological oxidation with pseudomonas putida (S)-8-hydroxy-iso-butyric acid (3) has been prepared. From this ((pseudosymmetrical D (see text) intermediate the two enantiomeric bromo derivatives 8 (R) and 20 (S) have been synthesized (cf. scheme 4) by altering the sequence of the reactions (cf. scheme 3). A Grignard reaction starting from the two bromo compounds 8 and 20 and ...
