Organic letters

Palladium-catalyzed cross-coupling reactions of carboxylic anhydrides with organozinc reagents

D Wang, Z Zhang

Index: Wang, Donghui; Zhang, Zhaoguo Organic Letters, 2003 , vol. 5, # 24 p. 4645 - 4648

Full Text: HTML

Citation Number: 64

Abstract

Negishi-type cross-coupling reaction was effected by employing organozincs and anhydrides or mixed anhydrides that formed in situ from sodium salts of the corresponding acids and ethyl chloroformate under the catalysis of palladium (0). A general method for preparing symmetrical/unsymmetrical ketones was developed.

 Related Synthetic Route

~78%

~76%

~75%

~94%

~83%

~62%

~91%

~68%

~70%

~89%

~86%

~70%

~86%

~84%

~66%

~76%

~74%

~65%

~85%

~76%

~80%

~97%

~92%

~69%

~61%