Tetrahedron Letters

Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins

SK Ghosh, MS Butler, MJ Lear

Index: Ghosh, Shibaji K.; Butler, Mark S.; Lear, Martin J. Tetrahedron Letters, 2012 , vol. 53, # 22 p. 2706 - 2708

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Citation Number: 2

Abstract

The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway.