7a, b showed that the a and@ OH isomers were of similar reactivity for each substrate. In contrast, while lla-hydroxyprogesterone 7a was smoothly oxidized to the 11-keto product, the llp-hydroxy isomer 7b, which has a more hindered axial OH group, was unreactive under the same conditions.
![1-methoxy-4-[1-(1-phenylethoxy)ethyl]benzene Structure](https://image.chemsrc.com/caspic/455/88288-59-9.png)
