An Effective Minor Groove Binder as a Red Fluorescent Marker for Live??Cell DNA Imaging and Quantification

…, J Fan, J Wang, S Zhang, F Song, S Sun

Index: Peng, Xiaojun; Wu, Tong; Fan, Jiangli; Wang, Jingyun; Zhang, Si; Song, Fengling; Sun, Shiguo Angewandte Chemie - International Edition, 2011 , vol. 50, # 18 p. 4180 - 4183

Full Text: HTML

Citation Number: 61

Abstract

Since the understanding of DNA organization and structure in vivo is so important, fluorescent staining techniques using organic DNA-binding molecules are required for biological research and medical diagnosis, including cellular imaging and DNA quantification.[1–5] However, membrane-permeable DNA-specific stains are uncommon. The minor groove binders 4', 6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 are ...