Abstract The present study describes the synthesis of fifteen 2-(9-oxoacridin-10 (9H)-yl)-N- phenyl acetamide derivatives (13a–o) through condensation of 2-chloro-N-phenyl acetamides (12a–o) with acridone molecule (10). All the synthesized compounds were screened for their anti-cancer activity against three diverse cell lines including breast (MCF- 7), cervical (HeLa) and lung adenocarcinoma (A-549) employing standard MTT assay. ...