Abstract The total synthesis of sequential oligomers of retro-peptides of the general formula Boc (-gGly-mAib) n-OBn, starting from dimethylmalonic acid, has been carried out in good overall yield. The key step is the formation of the gGly unit> N− CH 2− N<, which is easily obtained in a one-pot/three-step reaction from BnO-mAib-Gly-OH and diphenylphosphoryl azide. The synthesis of the sequential oligomers of RCO (-gAla-mAib) n-OR′ was also ...
