Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents

J Wu, L Yu, F Yang, J Li, P Wang, W Zhou, L Qin…

Index: Wu, Jing; Yu, Linxi; Yang, Feifei; Li, Jingjie; Wang, Peng; Zhou, Wenbo; Qin, Liwen; Li, Yunqi; Luo, Jian; Yi, Zhengfang; Liu, Mingyao; Chen, Yihua European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 340 - 351

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Citation Number: 13

Abstract

Abstract A series of 2, 3-diaryl-4-thiazolidinone derivatives were synthesized and evaluated for their antiproliferative properties against two well-known cancer cell lines (A549 as human lung cancer and MDA-MB-231 as human breast cancer). Structure activity relationship (SAR) analysis resulted in the discovery of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2- methoxy-phenyl)-4-thiazolidinone derivatives with high potent inhibitory effects on the ...