Conformational transmission in four-and five-coordinated phosphorus compounds. Solvent effects on the conformation in 5'-phosphorylated model nucleosides

LH Koole, JL Van Kooyk, HM Buck

Index: Koole, Leo H.; Kooyk, Raymond J. L. van; Buck, Henk M. Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 4032 - 4037

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Citation Number: 13

Abstract

Abstract: The C4,-C5, conformation of the 5'-PIV model compounds 1-3 and the 5'-Pv TBP model compounds 4-6 has been determined in various solvents with 300-and 500-MHz 'H NMR. It is found that lowering the solvent polarity results in a substantial increase of the g- populations for the model compounds 1, 2, 4, and 5 (eg, for 1 in D20, x (g)= 0.00; CCI4, x (g- )= 0.23). This effect can be attributed to an enhanced electrostatic repulsion between the ...