Journal of the American Chemical Society

Diselenides and allyl selenides as glutathione peroxidase mimetics. Remarkable activity of cyclic seleninates produced in situ by the oxidation of allyl ω-hydroxyalkyl …

TG Back, Z Moussa

Index: Back, Thomas G.; Moussa, Ziad Journal of the American Chemical Society, 2003 , vol. 125, # 44 p. 13455 - 13460

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Citation Number: 205

Abstract

A series of aliphatic diselenides and selenides containing coordinating substituents was tested for glutathione peroxidase (GPx)-like catalytic activity in a model system in which the reduction of tert-butyl hydroperoxide with benzyl thiol to afford dibenzyl disulfide and tert- butyl alcohol was performed under standard conditions and monitored by HPLC. Although the diselenides showed generally poor catalytic activity, allyl selenides proved more ...