Abstract 2-Chlorotetrahydrofuran (2-Cl-THF) is formed in 85% yield by reaction of sulfuryl chloride with excess THF. 2-Cl-THF reacts with alcohols, phenols, acids, thiols, azoles, amides and imides to give the corresponding tetrahydro-2-furanyl derivatives. Reaction with uracil derivatives provides N 1-and N 3-monosubstituted and N 1, N 3-disubstituted compounds. The reaction with alcohols provides a convenient general procedure for ...
