Abstract: The syntheses of 7-chloro-, 7-methoxy-, and?-acetoxy-7, 12-dihydropleiadenes have been accomplished and the conformational preferences of these groups, as well as a 7- phenyl group, established as axial. Evidence for these conclusions is obtained from nmr spectroscopy, using conformationally homogeneous model 7, 12-dihydropleiadenes of known stereochemistry, and evaluation of long-range coupling between C, and Clz ...
