Synthesis of compounds with antiproliferative activity as analogues of prenylated natural products existing in Brazilian propolis

…, J Carvalho, G Hamilton, D Rando, J Quincoces

Index: Pisco, Laura; Kordian, Marcus; Peseke, Klaus; Feist, Holger; Michalik, Dirk; Estrada, Ernesto; Carvalho, Joao; Hamilton, Gerhard; Rando, Daniela; Quincoces, Jose European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 401 - 407

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Citation Number: 46

Abstract

This work describes the syntheses and antitumoral properties of five prenyl compounds from which antiproliferative activities were predicted by using the TOPS-MODE approach, a computational method for drug design. The syntheses of 2-(3-methylbut-2-enyloxy) acetophenone (2), 2-hydroxy-5-(3-methylbut-2-enyl) acetophenone (3), 2-hydroxy-3-(1, 1- dimethylallyl) acetophenone (4), and 5-(3-methylbut-2-enyl)-2-(3-methylbut-2-enyloxy) ...