Tetrahedron

Expeditious synthesis of nicotianamine and 2′-deoxymugineic acid

K Miyakoshi, J Oshita, T Kitahara

Index: Miyakoshi, Katsuhiro; Oshita, Jun; Kitahara, Takeshi Tetrahedron, 2001 ,  vol. 57,  # 16  p. 3355 - 3360

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Citation Number: 31

Abstract

A simple and efficient method of synthesizing nicotianamine 4 and 2′-deoxymugineic acid 3 was devised. We employed thioamide as an intermediate and the title compounds (4 and 3) were afforded via chemoselective reduction of the thioamides in 33% overall yield through 7 steps and 30% overall yield through 8 steps, respectively.