Chemical constituents from Piper marginatum Jacq.(Piperaceae)—antifungal activities and kinetic resolution of (RS)-marginatumol by Candida antarctica lipase ( …

JB Reigada, CM Tcacenco, LH Andrade, MJ Kato…

Index: Reigada, Juliana B.; Tcacenco, Celize. M.; Andrade, Leandro H.; Kato, Massuo J.; Porto, Andre L.M.; Lago, Joao Henrique G. Tetrahedron Asymmetry, 2007 , vol. 18, # 9 p. 1054 - 1058

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Citation Number: 26

Abstract

The leaves of Piper marginatum contain the antifungal compounds 3, 4- methylenedioxypropiophenone 1, 2-methoxy-4, 5-methylenedioxypropiophenone 2, 1-(3, 4- methylenedioxyphenyl) propan-1-ol 3 (marginatumol), 5, 4′-dihydroxy-7-methoxyflavanone 4 and 5, 7-dihydroxy-4′-methoxyflavanone 5. The absolute configuration of natural marginatumol was determined as (+)-(R)-3 (ee 48%) by comparison of its optical ...