1, 3, 4-Oxadiazole/thiadiazole and 1, 2, 4-triazole derivatives of biphenyl-4-yloxy acetic acid: Synthesis and preliminary evaluation of biological properties

H Kumar, SA Javed, SA Khan, M Amir

Index: Kumar, Harish; Javed, Sadique A.; Khan, Suroor A.; Amir, Mohammad European Journal of Medicinal Chemistry, 2008 , vol. 43, # 12 p. 2688 - 2698

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Citation Number: 184

Abstract

A series of 1, 3, 4-oxadiazole/thiadiazole and 1, 2, 4-triazole derivatives of biphenyl-4-yloxy acetic acid were synthesized in order to obtain new compounds with potential anti- inflammatory activity, analgesic activity and lower ulcerogenic potential. All compounds were evaluated for their anti-inflammatory activity by the carrageenan induced rat paw edema test method. The compounds possessing potent anti-inflammatory activity were further tested ...