Journal of heterocyclic chemistry

A mild, efficient and improved protocol for the friedländer synthesis of quinolines using lewis acidic ionic liquid

G Karthikeyan, PT Perumal

Index: Karthikeyan, Ganesan; Perumal, Paramasivan T. Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 1039 - 1041

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Citation Number: 50

Abstract

Introduction. The Friedländer condensation is still considered as the most popular method, which provides rapid access to quinolines and related aza aromatic compounds [1]. The quinoline derivatives display wide range of biological properties such as antiasthamatic [2], antiinflamatory [3], and tyrosine kinase PDGF-RTF inhibiting properties [4]. The potent biological properties have naturally received much attention of the synthetic community and several reports on the synthesis ...