Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors

…, A Lapucci, J Giuntini, E Orlandini, I Banti, E Nuti…

Index: Nencetti, Susanna; Mazzoni, Maria R.; Ortore, Gabriella; Lapucci, Annalina; Giuntini, Janette; Orlandini, Elisabetta; Banti, Irene; Nuti, Elisa; Lucacchini, Antonio; Giannaccini, Gino; Rossello, Armando European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 825 - 834

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Citation Number: 8

Abstract

With the aim of obtaining compounds possessing high SERT selectivity, in the present work we synthesized and studied the inhibition of serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters by docking studies and experimental binding measurements of a series of 4-(aryl) piperidin-3-one O-4-benzyl oxime hydrochlorides (1– 10) of both E and Z configuration. E configuration compounds showed high SERT binding ...