Alkylation of Substituted Benzoic Acids in a Continuous Flow Microfluidic Microreactor: Kinetics and Linear Free Energy Relationships

A Gholamipour-Shirazi, C Rolando

Index: Gholamipour-Shirazi, Azarmidokht; Rolando, Christian Organic Process Research and Development, 2012 , vol. 16, # 5 p. 811 - 818

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Citation Number: 9

Abstract

Alkylation of para-substituted benzoic acids by iodomethane using an organic superbase, 1, 8-bis (tetramethylguanidino) naphthalene (TMGN) in DMF was chosen as a model reaction to test the quality of the control of experimental parameters in a continuous flow microfluidic reactor as it is expected to follow a perfect second order kinetics with a large dynamics by varying the substituents. These conditions may be directly used for the synthesis of natural ...

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