Evaluation of copper chelation agents as anti-angiogenic therapy

…, S Tantama, S Sankineni, T Scott, C Menard…

Index: Camphausen, Kevin; Sproull, Mary; Tantama, Steve; Sankineni, Sandeep; Scott, Tamalee; Menard, Cynthia; Coleman, C.Norman; Brechbiel, Martin W. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 19 p. 4287 - 4293

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Citation Number: 15

Abstract

The design, synthesis and evaluation of N, N′, N′′-tris (2-pyridylmethyl)-cis, cis-1, 3, 5,- triaminocyclohexane (tachpyr, 1) derivatives as novel anti-angiogenic agents were performed in an in vitro endothelial cell proliferation assay to assess their cytotoxicity and selectivity. The selective nature of the anti-angiogenic agents for human umbilical vein endothelial cells (Huvec) was compared to a normal fibroblast cell line and a human ...