Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic

AP Combs, W Zhu, ML Crawley, B Glass…

Index: Journal of Medicinal Chemistry, , vol. 49, # 13 p. 3774 - 3789

Full Text: HTML

Citation Number: 77

Abstract

... Journal of Medicinal ... 2,3 Thus, a potent cell permeable inhibitor of PTP1B has been sought by nearly all pharmaceutical companies to test ... 4. Medicinal chemistry efforts to date have focused on the identification of inhibitors that contain strong binding, nonhydrolysable tyrosine ...

Potent benzimidazole sulfonamide protein tyrosine phosphatas...

[Combs, Andrew P.; Zhu, Wenyu; Crawley, Matthew L.; Glass, Brian; Polam, Padmaja; Sparks, Richard B.; Modi, Dilip; Takvorian, Amy; McLaughlin, Erin; Yue, Eddy W.; Wasserman, Zelda; Bower, Michael; Wei, Min; Rupar, Mark; Ala, Paul J.; Reid, Brian M.; Ellis, Dawn; Gonneville, Lucie; Emm, Thomas; Taylor, Nancy; Yeleswaram, Swamy; Li, Yanlong; Wynn, Richard; Burn, Timothy C.; Hollis, Gregory; Liu, Phillip C. C.; Metcalf, Brian Journal of Medicinal Chemistry, 2006 , vol. 49, # 13 p. 3774 - 3789]

Highly selective inhibitors of thromboxane synthetase. 2. Py...

[Journal of Medicinal Chemistry, , vol. 24, # 10 p. 1149 - 1155]

Parallel synthesis of aldehydes and ketone facilitated by a ...

[Journal of Organic Chemistry, , vol. 64, # 6 p. 1823 - 1830]

Highly selective inhibitors of thromboxane synthetase. 2. Py...

[Journal of Medicinal Chemistry, , vol. 24, # 10 p. 1149 - 1155]