(R)-3'-(3-Methylbenzo [b] thiophen-5-yl) spiro [1-azabicyclo [2, 2, 2] octane-3, 5'-oxazolidin]-2'-one, a Novel and Potent α7 Nicotinic Acetylcholine Receptor Partial …

…, A Numata, J Katayama, H Satoh, Y Shiigi…

Index: Tatsumi, Ryo; Fujio, Masakazu; Takanashi, Shin-Ichi; Numata, Atsushi; Katayama, Jiro; Satoh, Hiroyuki; Shiigi, Yasuyuki; Maeda, Jun-Ichi; Kuriyama, Makoto; Horikawa, Takashi; Murozono, Takahiro; Hashimoto, Kenji; Tanaka, Hiroshi Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4374 - 4383

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Citation Number: 43

Abstract

Recent studies have suggested that the α7 nicotinic acetylcholine receptors play important roles in learning and memory. Herein, we describe our research of the structure-activity relationships (SAR) in a series of (S)-spiro [1-azabicyclo [2.2. 2] octane-3, 5'-oxazolidin]-2'- ones bearing various bicyclic moieties to discover novel α7 receptor agonists. Through a number of SAR studies on the series, we have found out that inhibition of CYP 2D6 ...