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Silica Phosphoric Acid (SPA) as a Highly Active, Reusable, Heterogeneous Catalyst for the Synthesis of 2-Amino/Anilino-5-ARYL-1, 3, 4-Thiadiazine Bromide …
S Rostamizadeh, AM Amani…
Index: Rostamizadeh, Shahnaz; Amani, Ali Mohammad; Shadjou, Nasrin Phosphorus, Sulfur and Silicon and the Related Elements, 2012 , vol. 187, # 2 p. 238 - 244
Silica phosphoric acid has been found to be an efficient catalyst for the synthesis of 2- amino/anilino-5-aryl-1, 3, 4-thiadiazine bromide derivatives from the reaction of thiosemicarbazide and α-bromoketones in acetonitrile at room temperature. The catalyst can be reused for four times without any significant loss of catalytic activity. The experimental procedure is simple, and the products are obtained in high yield.
