Abstract N-Acetic acid derivatives of 4-carboxy-6-arylpyridazin-3-ones were synthesized for the dual purpose of inhibiting aldose reductase and exhibiting antioxidant properties. All the prepared compounds showed a significant in vitro aldose reductase inhibitory effect (10− 5 M≤ IC 50≤ 10− 4 M). The spatial configuration of the most active derivative 4f (4-i-PrC 6 H 4 at C 6, IC 50= 0 95× 10− 5 M) was compared with pharmacophore requirements of the ...
