A convergent approach to protein design. Metal ion-assisted spontaneous self-assembly of a polypeptide into a triple-helix bundle protein

MR Ghadiri, C Soares, C Choi

Index: Ghadiri, M. Reza; Soares, Christopher; Choi, Chong Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 825 - 831

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Citation Number: 230

Abstract

Abstract: A novel metal ion-assisted self-organizing molecular process is described by which a small peptide has been assembled into a large and topologically predetermined protein tertiary structure. The intrinsic binding energy of a metal ion coordination complex as well as the stringent geometrical requirements present for a strong metal ion-ligand interaction has been exploited to control the oligomeric state as well as the relative orientation of peptide ...