The disodium salts of N-trityl-hydroxyamino acids 2 prepared in situ with NaH, in the presence of imidazole, were selectively alkylated with alkyl iodides to give N-trityl-O-alkyl- hydroxyamino acids 3. Compounds 3 were readily converted to O-alkyl-hydroxyamino acids 5 or other intermediates useful for incorporation into a peptide chain. The applicability of these derivatives in the preparation of related peptides is illustrated by the synthesis of the ...
