Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease

X Zhang, AC Schmitt, W Jiang, Z Wasserman…

Index: Zhang, Xiaojun; Schmitt, Aaron C.; Jiang, Wen; Wasserman, Zelda; Decicco, Carl P. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1157 - 1160

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Citation Number: 38

Abstract

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease leading to cirrhosis, hepatocellular carcinoma or liver failure. 1 Current therapies involve treatment with interferon-α, either alone or in combination with ribavirin; however, poor efficacy and severe side effects are frequent. 2 There is thus an urgent need to discover inhibitors of HCV-specific proteins for the development of anti-HCV drugs. One of the most intensively studied and ...