A new type of enzymatic hydrolysis has been disclosed. A kind of yeast, Pichia miso, hydrolyzed enol esters such as 3-acetoxy-1-p-methoxybenzyloxy-2-methoxymethoxy-2- alkenes with differentiation of the enantiotopic face to afford optically active α-substituted ketones.
![2-[(4-methoxyphenyl)methoxy]oxirane Structure](https://image.chemsrc.com/caspic/391/192989-02-9.png)