Synthesis of a tritium??labelled diether analog of phosphatidylinositol 4, 5??bisphosphate

J Chen, GD Prestwich

Index: Chen, Jian; Prestwich, Glenn D. Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 3 p. 251 - 258

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Citation Number: 2

Abstract

Abstract The synthesis of 1-(1, 2-O-diundecyl-sn-glycerylphosphoryl) 4, 5-D-myo-inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically-pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP 2 and tritiation gave the high-specific activity, tritium- labelled analog.© 1997 John Wiley & Sons, Ltd.