Pyridazinones as selective cyclooxygenase-2 inhibitors

CS Li, C Brideau, CC Chan, C Savoie…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 4 p. 597 - 600

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Citation Number: 62

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... of 4 with 4-methylthiophenylboronic acid, followed by bromination and oxidiation yielded the 3-bromo-furan-2-one intermediate 5. This intermediate was then converted to the pyridazinone intermediate 8 using chemistry as described ...

Synthesis, characterization, and activity of metabolites der...

[Nicoll-Griffith, Deborah A.; Yergey, James A.; Trimble, Laird A.; Silva, Jose M.; Li, Chun; Chauret, Nathalie; Gauthier, Jacques Yves; Grimm, Erich; Leger, Serge; Roy, Patrick; Therien, Michel; Wang, Zhaoyin; Prasit, Peppi; Zamboni, Robert; Young, Robert N.; Brideau, Christine; Chan, Chi-Chung; Mancini, Joseph; Riendeau, Denis Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 23 p. 2683 - 2686]