Glycosyltransferases and glycosidases are important classes of enzymes responsible for the synthesis and degradation of oligosaccharides. 1 Development of specific inhibitors of such enzymes is of current interest as these inhibitors may be used as modulators to control cellular functions. Enzymatic hydrolysis of a glycosidic bond generally takes place via general acid and base catalysis that requires two critical residues, a proton donor and a nucleophile (Fig. ...
