e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs

ME Wall, MC Wani, AW Nicholas…

Index: Journal of Medicinal Chemistry, , vol. 36, # 18 p. 2689 - 2700

Full Text: HTML

Citation Number: 181

Abstract

... Reduction of the nitro groups of the various analogs 5a-e has at times presented difficulties. We have utilized 0 1993 American Chemical Society Page 2. 2690 Journal of Medicinal Chemistry, 1993, Vol. 36, No. 18 Chart I Wall et al. I 1 0 1 R 0 R 1 0 'I zoo ...

2,6-Dinitrobenzaldehyde Structure

2,6-Dinitrobenz...

~%

rubitecan Structure

2-amino-6-nitrobenzaldehyde ethylene acetal Structure

2-amino-6-nitro...

~%

rubitecan Structure

N/A Structure

~%

rubitecan Structure

9-Aminocamptothecin Structure

9-Aminocamptothecin

~59%

9-Hydroxycamptothecin Structure

9-Hydroxycampto...

Campathecin Structure

2,6-Dinitrobenzaldehyde Structure

2,6-Dinitrobenz...

~%

9-Hydroxycamptothecin Structure

9-Hydroxycampto...

(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione Structure

(S)-4-ethyl-4-h...

~%

9-Hydroxycamptothecin Structure

9-Hydroxycampto...

2-aMino-6-nitrobenzaldehyde Structure

2-aMino-6-nitro...

~%

9-Hydroxycamptothecin Structure

9-Hydroxycampto...

2-amino-6-nitrobenzaldehyde ethylene acetal Structure

2-amino-6-nitro...

~%

9-Hydroxycamptothecin Structure

9-Hydroxycampto...

N/A Structure

~%

9-Hydroxycamptothecin Structure

9-Hydroxycampto...

2,6-Dinitrobenzaldehyde Structure

2,6-Dinitrobenz...

~%

9-Aminocamptothecin Structure

9-Aminocamptothecin

2-amino-6-nitrobenzaldehyde ethylene acetal Structure

2-amino-6-nitro...

~%

9-Aminocamptothecin Structure

9-Aminocamptothecin

N/A Structure

~%

9-Aminocamptothecin Structure

9-Aminocamptothecin

(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione Structure

(S)-4-ethyl-4-h...

~%

9-Aminocamptothecin Structure

9-Aminocamptothecin

2-aMino-6-nitrobenzaldehyde Structure

2-aMino-6-nitro...

~%

9-Aminocamptothecin Structure

9-Aminocamptothecin

2,6-Dinitrobenzaldehyde Structure

2,6-Dinitrobenz...

~%

Campathecin Structure

(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione Structure

(S)-4-ethyl-4-h...

~%

Campathecin Structure

rubitecan Structure

~%

Campathecin Structure

2-aMino-6-nitrobenzaldehyde Structure

2-aMino-6-nitro...

~%

Campathecin Structure

2-amino-6-nitrobenzaldehyde ethylene acetal Structure

2-amino-6-nitro...

~%

Campathecin Structure

N/A Structure

~%

Campathecin Structure

Benzaldehyde,2-amino-5-nitro- Structure

Benzaldehyde,2-...

(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione Structure

(S)-4-ethyl-4-h...

~87%

9-Nitrocamptothecin Structure

9-Nitrocamptothecin

Benzaldehyde,2-amino-5-nitro- Structure

Benzaldehyde,2-...

~%

9-amino-20-camptothecin Structure

9-amino-20-camp...

(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione Structure

(S)-4-ethyl-4-h...

~%

9-amino-20-camptothecin Structure

9-amino-20-camp...

Radiosynthesis of carbon-11-labeled camptothecin derivatives...

[Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3865 - 3869]

A practical regiospecific synthesis of 9-nitrocamptothecin

[Synthesis, , # 12 p. 1940 - 1942]

A practical regiospecific synthesis of 9-nitrocamptothecin

[Synthesis, , # 12 p. 1940 - 1942]

A practical regiospecific synthesis of 9-nitrocamptothecin

[Synthesis, , # 12 p. 1940 - 1942]

Plant antitumor agents. 30. Synthesis and structure activity...

[Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700]