Abstract Treatment of 2-(tert-butyldimethylsilyl)-3-(triethylsilyloxymethyl) furan with 1.3 equiv. of n-BuLi (THF,− 40, 3h), followed by the addition of a variety of electrophiles provided 2, 3, 5- trisubstituted furans, which upon treatment with tetra-n-butylammonium fluoride afforded 2, 4- disubstituted furans in moderate to excellent yields.
