Synthetic communications

Asymmetric Synthesis of ω??Bromo??2 (S)??Methyl Acids as Precursors for Novel Arginine, Lysine, and Mercapto Residues

MK Hadden, KP Kokko, TA Dix

Index: Hadden, M. Kyle; Kokko, Kyle P.; Dix, Thomas A. Synthetic Communications, 2005 , vol. 35, # 12 p. 1675 - 1680

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Citation Number: 5

Abstract

Abstract A series of ω??bromo??2 (S)??methyl acids has been synthesized as precursors of novel arginine (Arg), lysine (Lys), and mercapto analogues. These intermediates contain α?? methyl groups and are designed to mask the N??terminal amine when incorporated in pharmaceutically relevant peptides.