The female sex hormone estradiol (1) has a variety of beneficial and detrimental effects in women.'The triphenylethylene class of non-steroidal estrogens (eg, tamoxifen, 2) shows tissue-dependent expression of estrogen agonist and antagonist activity and may represent a significant advance over conventional hormone replacement therapy with 1 for prevention of osteoporosis and cardiovascular disease in postmenopausal women2 (Figure 1). The ...
