Abstract 2-Methoxy-4-amino-5-pyrimidinecarbaldehyde (2a) as well as its 6-methyl 2b and 6- phenyl derivatives 2c were prepared by reduction of the corresponding aminopyrimidinecarbonitriles 1. Catalytic hydrogenation of 1a, 1b gives 5- hydroxymethylpyrimidines 3a, 3b; under the same conditions 1c afforded 5- aminomethylpyrimidine 4. Condensation of 2 with carbonitriles, ketones and ...
