Heterogeneous DNA adduct formation in vitro by the acetylated food mutagen 2-(acetoxyamino)-1-methyl-6-phenylimidazo [4, 5-b] pyridine: a fluorescence …

GA Marsch, EN Goldman, E Fultz…

Index: Marsch, Glenn A.; Goldman, Eli N.; Fultz, Esther; Shen, Nancy H.; Turteltaub, Kenneth W. Chemical Research in Toxicology, 1995 , vol. 8, # 5 p. 659 - 670

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Citation Number: 9

Abstract

The food mutagen 2-amino-l-methyl-6-phenylimidazo [4, 5-blpyridine (PhIP) forms adducts to DNA guanine bases at the C-8 position. No other DNA adduction site has been verified for PhIP, nor has any experimental data been collected on the conformation of the PhIP-DNA covalent complex. To determine if multiple PhIP-DNA adduct species exist, or if PhIP-DNA adducts assume multiple conformations, 2-(acetoxyamino)-l-methyl-6-phenylimidazo~ 4, 5 ...