CNS stimulant effect of N-acylderivatives of glutamic and aspartic acids

…, OV Kononov, MA Dumpis, LB Piotrovskii

Index: Garyaev, A. P.; Kononov, O. V.; Dumpis, M. A.; Piotrovskii, L. B. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 5 p. 335 - 338 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 5 p. 20 - 22

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Abstract

In the course of searching for biologically active substances among derivatives of glutamic and aspartic acid by employing experiments on radioligand binding [4], we have shown that certain N-and O-derivatives of these stimulant amino acids (SAA) can interact with" glutamaterecognizing sites" of rat brain synaptic membranes. We studied the biological activity of N-acyl derivatives of glutamic and aspartic acid (I-XVII) by injecting them directly ...