Synthesis and biological studies of some novel antiinflammatory aryl-hydroxy-amino-ketones

…, L Hadjipetrou-Kourounakis, P Kourounakis

Index: Hadjipavlou-Litina, D; Rekka, E; Hadjipetrou-Kourounakis, L; Kourounakis, P European Journal of Medicinal Chemistry, 1991 , vol. 26, # 1 p. 85 - 90

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Citation Number: 15

Abstract

Abstract The synthesis of some 4-hydroxy-(or amino)-ethyl-amino butyrophenones or butyrothienones is described. The inter-conversion of these compounds to the corresponding 5-aryl-4-oxa-1-azabicyclo [3, 3, 0] octanes is presented. The title compounds demonstrated good antiinflammatory activity in the adjuvant induced disease model. They also possessed antinociceptive, immunomodulating and antioxidant activity, properties ...