An ionic liquid mediated Friedel-Crafts addition of arenes to isothiocyanates

…, SJ Nara, JR Harjani, MM Salunkhe

Index: Naik, Prashant U.; Nara, Susheel J.; Harjani, Jitendra R.; Salunkhe, Manikrao M. Canadian Journal of Chemistry, 2003 , vol. 81, # 10 p. 1057 - 1060

Full Text: HTML

Citation Number: 18

Abstract

A new protocol is developed for the synthesis of N-substituted thioamides, employing arenes and isothiocyanates in 1-butyl-3-methylimidazolium chloroaluminate ionic liquid,[bmim] Cl⊙ 2AlCl3, as a homogenous Lewis acid catalyst and solvent. The effect of Lewis acidity and the stoichiometry of the ionic liquid on the extent of product formation is studied. Studies reveal that a progressive increase in yields was observed with increasing Lewis acidity, ...