Synthesis of [18F] BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging

…, D Wan, SA Hilderbrand, R Weissleder…

Index: Hendricks, J. Adam; Keliher, Edmund J.; Wan, Dongpeng; Hilderbrand, Scott A.; Weissleder, Ralph; Mazitschek, Ralph Angewandte Chemie - International Edition, 2012 , vol. 51, # 19 p. 4603 - 4606

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Citation Number: 55

Abstract

Fluorescence-based intravital imaging approaches have been essential for studying the function and distribution of biologically active small molecules and their molecular targets in vivo.[1] While optical imaging enables visualization over a broad scope of spatial resolution ranging from subcellular to whole-body anatomical imaging, its application is constrained by the optical transparency of tissues. Optical imaging modalities are thus better suited for ...