New N-(benzhydryloxyalkyl)-4-(carboxy/carbamoylmethyl) piperidine derivatives with antidepressant activity

…, JF Teste, MJ Cedat, PY Fiez-Vandal, R Dokhan…

Index: Ahmad, Y. El; Maillet; Laurent; Talab; Teste; Cedat; Fiez-Vandal; Dokhan; Ollivier European Journal of Medicinal Chemistry, 1997 , vol. 32, # 3 p. 205 - 218

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Citation Number: 7

Abstract

Several benzhydryloxylalkylpiperidine derivatives were prepared with the aim of obtaining new antidepressant compounds. The influence of the length of the aliphatic chain and of aromatic and piperidine ring substitutions was studied. The pharmacological activity of compounds was investigated in vivo by means of a screening comprising four pharmacological tests: antagonism of reserpine and apomorphine hypothermia; increase ...