The rational design and mechanistic understanding of catalytic systems capable of generating quaternary stereocenters in an asymmetric fashion is a recognized challenge in synthesis.[1] A number of asymmetric Lewis base mediated processes have been developed within this area,[2] in which enantiomerically pure derivatives of 4-(pyrrolidino) pyridine (PPY) and 4-dimethylaminopyridine (DMAP) are elegantly employed by the Fu,[3] ...
