Condensed pyridazines. V Reactions of 7-(methylsulfonyl)-1-phenyl-1H-1, 2, 3-triazolo [4, 5-d] pyridazine with methoxide ion, Grignard reagents, hydrazines, and …

…, A YAMADA, E HAYASHI, T HIGASHINO

Index: Oishi, Etsuo; Yamada, Akiya; Hayashi, Eisaku; Higashino, Takeo Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 514 - 523

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Citation Number: 2

Abstract

Nucleophiles were found to react with 7-(methylsulfonyl)-1-phenyl-1H-1, 2, 3-triazolo [4, 5-d]- pyridazine (1) in three ways, depending on the nature of the reagent. One is substitution of the methylsulfonyl group in 1 by the reagent. The second one is addition of the reagent to the 4, 5-double bond in 1. The third one is the addition of the reagent, followed by ring fission of the pyridazine moiety. Thus, the reaction of 1 with sodium methoxide resulted in ...