Synthesis of Benzo [b] imidazo [1, 5-d][1, 5]-thiazepines. Derivatives of a Novel Ring System

…, O Petrov, A Antonova, V Kalcheva

Index: Petrova; Petrov; Antonova; Kalcheva Synthetic Communications, 2003 , vol. 33, # 24 p. 4355 - 4366

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Abstract

Abstract Derivatives of a novel tricyclic system having a 1, 5-benzothiazepine skeleton are described. A method for synthesis of the title compounds 5, consisted of an intramolecular cyclization of 1-(2-carboxymethylthiophenyl)-2 H-imidazol-2-ones 4 in PPA, is presented. Compounds 4 were prepared by a reaction of 1-(2-mercaptophenyl)-2 H-imidazol-2-ones 3 with chloroacetic acid. 2 H-Imidazolones 3 were obtained by a ring transformation of ...